St. John's Wort
Hypericum perforatum
Temperate Europe · wild-gathered flowering tops
Traditional mood-support botanical, standardised for hypericin and hyperforin.
Used in: JCMS Multi-Purpose · JCMS for Women
- Mood & emotional resilience88%
- Antioxidant density (ORAC)72%
- Traditional use record95%
- Clinical study volume84%
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St. John's Wort has been used in European traditional medicine since antiquity for low mood and nervous exhaustion. Its two most studied constituents, hypericin and hyperforin, are associated with serotonin, dopamine and noradrenaline reuptake modulation. Clinical reviews of mild to moderate low mood report effect sizes comparable with standard first-line options at 300 mg standardised extract, three times daily. Important: it induces the CYP3A4 liver enzyme, so it can reduce the effect of oral contraceptives, anticoagulants and antiretrovirals. JCMS includes it at a culinary infusion level, not a clinical dose.
